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Its strongest genetic-study result is p = 10−11, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 7,836 African American or Afro-Caribbean cases, 40,175 African American or Afro-Caribbean controls, 4,625 Hispanic or Latin American cases, 21,803 Hispanic or Latin American controls, 470 East Asian ancestry cases, 2,711 East Asian ancestry controls, 63,608 European ancestry cases, 229,593 European ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.0733 lower (95% confidence interval 0.054-0.092); p = 5 × 10−12.
How common The T allele had a frequency of about 90% in the people studied.
Where it sits Chromosome 13, band 13q14.3 — in an intron of RNASEH2B.
What each result means
A/ANo copy of the version the research linked to Enlarged prostate (Benign prostatic hyperplasia). This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Enlarged prostate (Benign prostatic hyperplasia). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Enlarged prostate (Benign prostatic hyperplasia). That is the strongest link of the three results. A link in a study is not a diagnosis.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs80262144
What is rs80262144?
rs80262144 is a single position in the genome, in or near the RNASEH2B gene. Published research associates it with enlarged prostate (benign prostatic hyperplasia). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs80262144 linked to?
On MyGeneLog this position is linked to Benign Prostatic Hyperplasia. The research behind each link, and its sources, are set out on that condition page.
Does having rs80262144 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs80262144 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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