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Who was studied 12,194 European and unknown ancestry cases, 28,072 European and unknown ancestry controls.
The effect
Each copy of the C allele carried 1.13 times the odds of Crohn's disease (95% confidence interval 1.09–1.18); p = 4 × 10−8.
How common The C allele had a frequency of about 11% in the people studied.
Where it sits Chromosome 13, band 13q14.11 — in an intron of LINC02341.
What each result means
C/CTwo copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
Nature genetics · 2017 · PMID 28067908 · open access
Questions about rs80244186
What is rs80244186?
rs80244186 is a single position in the genome, in or near the AKAP11 gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs80244186 linked to?
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs80244186 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs80244186 come from?
GWAS Catalog, Nat Genet 2017, PMID:28067908. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 3132116223110Reads by AI crawlersClaude3ChatGPT2Google · Gemini1Perplexity1Meta AI6Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others10Total31Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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