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Prostate-specific antigen levels

SERPINA3 · rs8023057

Where this position leads

Condition: Prostate-Specific Antigen (PSA) Levels

What the study found

Who was studied 28,503 European ancestry individuals; replicated in 2,716 Latino individuals, 2,518 East Asian ancestry individuals, 1,585 African American individuals, 6,193 European ancestry individuals (later diagnosed with prostate cancer), 5,603 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0607 higher (95% confidence interval 0.046-0.076); p = 2 × 10⁻¹⁵.

How common The A allele had a frequency of about 82% in the people studied.

Where it sits Chromosome 14, band 14q32.13 — between genes, 0.6 kb from ADIPOR1P2.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Prostate-specific antigen levels compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Prostate-specific antigen levels.

G/G Published research associates this genotype with typical/baseline likelihood of Prostate-specific antigen levels — no copies of the reported risk allele.

Source

Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer

Hoffmann TJ, Passarelli MN, Graff RE, Emami NC, Sakoda LC, Jorgenson E, Habel LA, Shan J, Ranatunga DK, Quesenberry CP, Chao CR, Ghai NR

and 17 more — show all

Aaronson D, Presti J, Nordström T, Wang Z, Berndt SI, Chanock SJ, Mosley JD, Klein RJ, Middha M, Lilja H, Melander O, Kvale MN, Kwok PY, Schaefer C, Risch N, Van Den Eeden SK, Witte JS

Nature communications · 2017 · PMID 28139693 · open access

Questions about rs8023057

What is rs8023057?

rs8023057 is a single position in the genome, in or near the SERPINA3 gene. Published research associates it with prostate-specific antigen levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs8023057 linked to?

On MyGeneLog this position is linked to Prostate-Specific Antigen (PSA) Levels. The research behind each link, and its sources, are set out on that condition page.

Does having rs8023057 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8023057 come from?

GWAS Catalog, Nat Commun 2017, PMID:28139693. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Prostate-specific antigen levels (rs8023057). MyGeneLog™. https://www.mygenelog.com/variants/rs8023057

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