1 2727123210Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity2Meta AI7Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others10Total27Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 523,783 European ancestry individuals; replicated in 59,206 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0166 higher (95% confidence interval 0.011-0.023); p = 4 × 10−8.
How common The G allele had a frequency of about 6% in the people studied.
Where it sits Chromosome 1, band 1q25.3 — in an intron of CACNA1E.
What each result means
G/GTwo copies of the version the research linked to Neuroticism. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Neuroticism. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Neuroticism. This is the starting point the study compared everyone against.
rs80223426 is a single position in the genome, in or near the CACNA1E gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs80223426 linked to?
On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.
Does having rs80223426 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs80223426 come from?
GWAS Catalog, Nat Genet 2019, PMID:30643256. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 2727123210Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity2Meta AI7Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others10Total27Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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