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Its strongest genetic-study result is p = 10−59, with 10 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 169,545 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0468 lower (95% confidence interval 0.039-0.055); p = 7 × 10−31.
How common The T allele had a frequency of about 74% in the people studied.
Where it sits Chromosome 14, band 14q32.32 — between genes, 4.4 kb from MARK3.
How common each version is
CT
KoreanKRGDB
C 71.3% · T 28.7%
KoreanKorea4K
C 69.9% · T 30.1%
KoreanKorea1K
C 71.0% · T 29.0%
Japanese ToMMo
C 63.3% · T 36.7%
Vietnamese
C 52.8% · T 47.2%
World gnomAD
C 39.6% · T 60.5%
World 1000 Genomes
C 49.6% · T 50.4%
World TOPMed
C 40.2% · T 59.8%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
What each result means
C/CNo copy of the version the research linked to Granulocyte percentage of myeloid white cells. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Granulocyte percentage of myeloid white cells. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Granulocyte percentage of myeloid white cells. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs8020912 is a single position in the genome, in or near the MARK3 gene. Published research associates it with granulocyte percentage of myeloid white cells. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs8020912 linked to?
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs8020912 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs8020912 come from?
GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Granulocyte percentage of myeloid white cells (rs8020912). MyGeneLog™. https://www.mygenelog.com/variants/rs8020912