Standard

Polyunsaturated fatty acids to monounsaturated fatty acids ratio

MIA2 · rs8018486

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the G allele shifted the measure 0.02 ratio higher (95% confidence interval 0.02-0.02); p = 2 × 10−10.

Where it sits Chromosome 14, band 14q21.1 — in an intron of MIA2.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Polyunsaturated fatty acids to monounsaturated fatty acids ratio — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Polyunsaturated fatty acids to monounsaturated fatty acids ratio.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Polyunsaturated fatty acids to monounsaturated fatty acids ratio compared to the general population.
Source

Questions about rs8018486

What is rs8018486?

rs8018486 is a single position in the genome, in or near the MIA2 gene. Published research associates it with polyunsaturated fatty acids to monounsaturated fatty acids ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs8018486 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8018486 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Polyunsaturated fatty acids to monounsaturated fatty acids ratio (rs8018486). MyGeneLog™. https://www.mygenelog.com/variants/rs8018486

← See all variants