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Inguinal hernia

near MIR217HG · rs80172616

Where this position leads

What the study found

Who was studied 32,089 European, African, Asian, Hispanic/Latin American or mixed ancestry male cases, 196,784 European, African, Asian, Hispanic/Latin American or mixed ancestry male controls.

The effect The reported allele is G; the catalogue records no effect size ; p = 2 × 10⁻³⁸.

Where it sits Chromosome 2, band 2p16.1 — between genes, 0.8 kb from MIR217HG.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Inguinal hernia — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Inguinal hernia.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Inguinal hernia compared to the general population.

Source

Ancestry- and sex-specific effects underlying inguinal hernia susceptibility identified in a multiethnic genome-wide association study meta-analysis

Choquet H, Li W, Yin J, Bradley R, Hoffmann TJ, Nandakumar P, Mostaedi R, Tian C, Ahituv N, Jorgenson E

23 and Me Research Team

Human molecular genetics · 2022 · PMID 35022708 · open access

Questions about rs80172616

What is rs80172616?

rs80172616 is a single position in the genome, in or near the near MIR217HG gene. Published research associates it with inguinal hernia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs80172616 linked to?

On MyGeneLog this position is linked to Inguinal Hernia. The research behind each link, and its sources, are set out on that condition page.

Does having rs80172616 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs80172616 come from?

GWAS Catalog, Human molecular genetics 2022, PMID:35022708. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Inguinal hernia (rs80172616). MyGeneLog™. https://www.mygenelog.com/variants/rs80172616

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