Sensitive

Non-cardia gastric cancer

ASH1L · rs80142782

Where this position leads

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹⁹, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 2,031 Han Chinese ancestry cases, 4,970 Han Chinese ancestry controls; replicated in 3,564 Han Chinese ancestry cases, 4,637 Han Chinese ancestry controls.

The effect Each copy of the T allele carried 1.61 times the odds of Non-cardia gastric cancer (95% confidence interval 1.45-1.79); p = 2 × 10⁻¹⁹.

How common The T allele had a frequency of about 93% in the people studied.

Where it sits Chromosome 1, band 1q22 — in an intron of ASH1L.

How common each version is

CT

Korean KRGDB

C 7.0% · T 93.0%

Korean Korea4K

C 5.9% · T 94.1%

Korean Korea1K

C 6.5% · T 93.5%

Japanese ToMMo

C 2.9% · T 97.0%

Vietnamese

C 19.2% · T 80.8%

World gnomAD

C 0.4% · T 99.6%

World 1000 Genomes

C 2.6% · T 97.4%

World TOPMed

C 0.4% · T 99.6%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C No copy of the version the research linked to Non-cardia gastric cancer. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Non-cardia gastric cancer. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Non-cardia gastric cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies

Wang Z, Dai J, Hu N, Miao X, Abnet CC, Yang M, Freedman ND, Chen J, Burdette L, Zhu X, Chung CC, Ren C

and 35 more — show all

Dawsey SM, Wang M, Ding T, Du J, Gao YT, Zhong R, Giffen C, Pan W, Koh WP, Dai N, Liao LM, Yan C, Qiao YL, Jiang Y, Shu XO, Chen J, Wang C, Ma H, Su H, Zhang Z, Wang L, Wu C, Xiang YB, Hu Z, Yuan JM, Xie L, Zheng W, Zheng W, Lin D, Chanock SJ, Shi Y, Goldstein AM, Jin G, Taylor PR, Shen H

Gut · 2017 · PMID 26701879 · open access

Questions about rs80142782

What is rs80142782?

rs80142782 is a single position in the genome, in or near the ASH1L gene. Published research associates it with non-cardia gastric cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs80142782 linked to?

On MyGeneLog this position is linked to Non-Cardia Gastric Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs80142782 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs80142782 come from?

GWAS Catalog, Gut 2015, PMID:26701879. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Non-cardia gastric cancer (rs80142782). MyGeneLog™. https://www.mygenelog.com/variants/rs80142782

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