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Prostate-specific antigen levels

near KLK5 · rs80122351

What the study found

Who was studied 85,824 European ancestry individuals, 3,509 African American or Afro-Caribbean individuals, 3,337 East Asian ancestry individuals, 3,098 Hispanic or Latin American individuals.

The effect Each copy of the G allele shifted the measure 0.03 higher (95% confidence interval 0.02-0.04); p = 1 × 10−10.

How common The G allele had a frequency of about 80% in the people studied.

Where it sits Chromosome 19, band 19q13.41 — between genes, 5.1 kb from KLK5.

What each result means

G/G Two copies of the version the research linked to Prostate-specific antigen levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Prostate-specific antigen levels. That is a smaller link than two copies.
T/T No copy of the version the research linked to Prostate-specific antigen levels. This is the starting point the study compared everyone against.
Source

Questions about rs80122351

What is rs80122351?

rs80122351 is a single position in the genome, in or near the near KLK5 gene. Published research associates it with prostate-specific antigen levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs80122351 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs80122351 come from?

GWAS Catalog, Nature medicine 2023, PMID:37264206. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Prostate-specific antigen levels (rs80122351). MyGeneLog™. https://www.mygenelog.com/variants/rs80122351

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