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Prostate-specific antigen levels

FERMT2 · rs8012109

What the study found

Who was studied 61,745 African ancestry individuals, 6,967 Asian ancestry individuals, 297,166 European ancestry individuals, 26,644 Hispanic or Latin American individuals.

The effect Each copy of the T allele shifted the measure 0.021 lower (95% confidence interval 0.016-0.026); p = 3 × 10−16.

Where it sits Chromosome 14, band 14q22.1 — in an intron of FERMT2.

What each result means

C/C No copy of the version the research linked to Prostate-specific antigen levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Prostate-specific antigen levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Prostate-specific antigen levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs8012109

What is rs8012109?

rs8012109 is a single position in the genome, in or near the FERMT2 gene. Published research associates it with prostate-specific antigen levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs8012109 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8012109 come from?

GWAS Catalog, Nature genetics 2025, PMID:39930085. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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Prostate-specific antigen levels (rs8012109). MyGeneLog™. https://www.mygenelog.com/variants/rs8012109

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