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Its strongest genetic-study result is p = 10−15, with 5 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.
The effect
Each copy of the A allele shifted the measure 0.02 % lower (95% confidence interval 0.02-0.02); p = 1 × 10−15.
Where it sits Chromosome 8, band 8q23.3 — in an intron of TRPS1.
What each result means
A/ATwo copies of the version the research linked to Phospholipids to Total Lipids in Very Small VLDL percentage. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Phospholipids to Total Lipids in Very Small VLDL percentage. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Phospholipids to Total Lipids in Very Small VLDL percentage. This is the starting point the study compared everyone against.
Nature genetics · 2025 · PMID 41044249 · open access
Questions about rs800911
What is rs800911?
rs800911 is a single position in the genome, in or near the TRPS1 gene. Published research associates it with phospholipids to total lipids in very small vldl percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs800911 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
Does having rs800911 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs800911 come from?
GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Phospholipids to Total Lipids in Very Small VLDL percentage (rs800911). MyGeneLog™. https://www.mygenelog.com/variants/rs800911