Standard
Primary sclerosing cholangitis
FOXP1 · rs80060485
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Primary sclerosing cholangitis compared to the general population.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Primary sclerosing cholangitis.
T/T
Published research associates this genotype with typical/baseline likelihood of Primary sclerosing cholangitis — no copies of the reported risk allele.
Source
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease
Ji SG,
Juran BD,
Mucha S,
Folseraas T,
Jostins L,
Melum E,
Kumasaka N,
Atkinson EJ,
Schlicht EM,
Liu JZ,
Shah T,
Gutierrez-Achury J
and 58 more — show all
Boberg KM,
Bergquist A,
Vermeire S,
Eksteen B,
Durie PR,
Farkkila M,
Müller T,
Schramm C,
Sterneck M,
Weismüller TJ,
Gotthardt DN,
Ellinghaus D,
Braun F,
Teufel A,
Laudes M,
Lieb W,
Jacobs G,
Beuers U,
Weersma RK,
Wijmenga C,
Marschall HU,
Milkiewicz P,
Pares A,
Kontula K,
Chazouillères O,
Invernizzi P,
Goode E,
Spiess K,
Moore C,
Sambrook J,
Ouwehand WH,
Roberts DJ,
Danesh J,
Floreani A,
Gulamhusein AF,
Eaton JE,
Schreiber S,
Coltescu C,
Bowlus CL,
Luketic VA,
Odin JA,
Chopra KB,
Kowdley KV,
Chalasani N,
Manns MP,
Srivastava B,
Mells G,
Sandford RN,
Alexander G,
Gaffney DJ,
Chapman RW,
Hirschfield GM,
de Andrade M,
Rushbrook SM,
Franke A,
Karlsen TH,
Lazaridis KN,
Anderson CA
Nature genetics · 2017 · PMID 27992413 · open access
Questions about rs80060485
What is rs80060485?
rs80060485 is a single position in the genome, in or near the FOXP1 gene. Published research associates it with primary sclerosing cholangitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs80060485 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs80060485 come from?
GWAS Catalog, Nat Genet 2016, PMID:27992413. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants