2 392229123117Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity2Meta AI9Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others17Total39Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied Up to 666 European ancestry trios, 399 European ancestry cases, 1,318 European ancestry controls; replicated in up to 795 East Asian ancestry trios.
The effect
Each copy of the A allele carried 1.35 times the odds of Orofacial clefts (95% confidence interval 1.141-1.607); p = 9 × 10−11.
Where it sits Chromosome 13, band 13q31.1 — in a non-coding transcript of LINC01080.
What each result means
A/ATwo copies of the version the research linked to Orofacial clefts. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Orofacial clefts. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Orofacial clefts. This is the starting point the study compared everyone against.
rs8001641 is a single position in the genome, in or near the SPRY2 gene. Published research associates it with orofacial clefts. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs8001641 linked to?
On MyGeneLog this position is linked to Cleft Lip and Palate. The research behind each link, and its sources, are set out on that condition page.
Does having rs8001641 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs8001641 come from?
GWAS Catalog, Nat Genet 2012, PMID:22863734. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 392229123117Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity2Meta AI9Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others17Total39Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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