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Who was studied 205 Sub-Saharan African ancestry cases, 2,159 Sub-Saharan African ancestry controls; replicated in 100 Sub-Saharan African ancestry cases, 79 African American cases, 648 Sub-Saharan African ancestry controls, 186 African American controls.
The effect
Each copy of the A allele shifted the measure 5.78 z-score higher; p = 7 × 10−9.
Where it sits Chromosome 2, band 2p12 — between genes, 169 kb from RN7SL201P.
What each result means
A/ATwo copies of the version the research linked to Cleft palate. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Cleft palate. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Cleft palate. This is the starting point the study compared everyone against.
rs80004662 is a single position in the genome, in or near the CTNNA2 gene. Published research associates it with cleft palate. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs80004662 linked to?
On MyGeneLog this position is linked to Cleft Lip with Cleft Palate. The research behind each link, and its sources, are set out on that condition page.
Does having rs80004662 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs80004662 come from?
GWAS Catalog, Human molecular genetics 2019, PMID:30452639. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 110Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot1Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total1Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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