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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 842,717 European ancestry individuals.
The effect
Each copy of the T allele carried 0.98 times the odds of Smoking initiation; p = 5 × 10−10.
Where it sits Chromosome 13, band 13q13.3 — in an intron of TRPC4.
What each result means
C/CNo copy of the version the research linked to Smoking initiation. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Smoking initiation. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Smoking initiation. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2020 · PMID 33082346 · open access
Questions about rs7993498
What is rs7993498?
rs7993498 is a single position in the genome, in or near the TRPC4 gene. Published research associates it with smoking initiation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs7993498 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7993498 come from?
GWAS Catalog, Nature communications 2020, PMID:33082346. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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