Standard

Triglyceride levels

near MLXIPL · rs799160

Strength of the evidence

3 / 4

Its strongest genetic-study result is p = 10−70, with 7 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 342,233 European ancestry individuals, 6,014 African ancestry individuals, 7,330 South Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0424 higher (95% confidence interval 0.038-0.047); p = 2 × 10−70.

Where it sits Chromosome 7, band 7q11.23 — between genes, 21.1 kb from MLXIPL.

How common each version is

CT
Korean KRGDB
C 19.7% · T 80.3%
Korean Korea4K
C 20.6% · T 79.4%
Japanese ToMMo
C 16.4% · T 83.6%
Vietnamese
C 32.6% · T 67.5%
World gnomAD
C 50.2% · T 49.8%
World 1000 Genomes
C 39.7% · T 60.3%
World TOPMed
C 50.6% · T 49.4%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C No copy of the version the research linked to Triglyceride levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Triglyceride levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Triglyceride levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs799160

What is rs799160?

rs799160 is a single position in the genome, in or near the near MLXIPL gene. Published research associates it with triglyceride levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs799160 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs799160 come from?

GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Triglyceride levels (rs799160). MyGeneLog™. https://www.mygenelog.com/variants/rs799160

← See all variants