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Uterine leiomyomata

FOXO1 · rs7986407

What the study found

Who was studied 38,466 European ancestry cases, 329,437 European ancestry controls.

The effect Each copy of the A allele carried 0.93 times the odds of Uterine leiomyomata (95% confidence interval 0.91-0.95); p = 2 × 10−18.

Where it sits Chromosome 13, band 13q14.11 — in an intron of FOXO1.

What each result means

A/A Two copies of the version the research linked to Uterine leiomyomata. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Uterine leiomyomata. That is a smaller link than two copies.
G/G No copy of the version the research linked to Uterine leiomyomata. This is the starting point the study compared everyone against.
Source

Questions about rs7986407

What is rs7986407?

rs7986407 is a single position in the genome, in or near the FOXO1 gene. Published research associates it with uterine leiomyomata. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7986407 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7986407 come from?

GWAS Catalog, Nature communications 2023, PMID:36726022. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Uterine leiomyomata (rs7986407). MyGeneLog™. https://www.mygenelog.com/variants/rs7986407

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