Sensitive

Endometrial cancer

KLF5 · rs7981863

Where this position leads

What the study found

Who was studied 12,906 European ancestry cases, 108,979 European ancestry controls.

The effect Each copy of the C allele carried 1.16 times the odds of Endometrial cancer (95% confidence interval 1.12-1.20); p = 3 × 10⁻¹⁷.

How common The C allele had a frequency of about 72% in the people studied.

Where it sits Chromosome 13, band 13q22.1 — between genes, 10.7 kb from RNY1P8.

What each result means

C/C Two copies of the version the research linked to Endometrial cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Endometrial cancer. That is a smaller link than two copies.

T/T No copy of the version the research linked to Endometrial cancer. This is the starting point the study compared everyone against.

Source

Identification of nine new susceptibility loci for endometrial cancer

O'Mara TA, Glubb DM, Amant F, Annibali D, Ashton K, Attia J, Auer PL, Beckmann MW, Black A, Bolla MK, Brauch H, Brenner H

and 114 more — show all

Brinton L, Buchanan DD, Burwinkel B, Chang-Claude J, Chanock SJ, Chen C, Chen MM, Cheng THT, Clarke CL, Clendenning M, Cook LS, Couch FJ, Cox A, Crous-Bous M, Czene K, Day F, Dennis J, Depreeuw J, Doherty JA, Dörk T, Dowdy SC, Dürst M, Ekici AB, Fasching PA, Fridley BL, Friedenreich CM, Fritschi L, Fung J, García-Closas M, Gaudet MM, Giles GG, Goode EL, Gorman M, Haiman CA, Hall P, Hankison SE, Healey CS, Hein A, Hillemanns P, Hodgson S, Hoivik EA, Holliday EG, Hopper JL, Hunter DJ, Jones A, Krakstad C, Kristensen VN, Lambrechts D, Marchand LL, Liang X, Lindblom A, Lissowska J, Long J, Lu L, Magliocco AM, Martin L, McEvoy M, Meindl A, Michailidou K, Milne RL, Mints M, Montgomery GW, Nassir R, Olsson H, Orlow I, Otton G, Palles C, Perry JRB, Peto J, Pooler L, Prescott J, Proietto T, Rebbeck TR, Risch HA, Rogers PAW, Rübner M, Runnebaum I, Sacerdote C, Sarto GE, Schumacher F, Scott RJ, Setiawan VW, Shah M, Sheng X, Shu XO, Southey MC, Swerdlow AJ, Tham E, Trovik J, Turman C, Tyrer JP, Vachon C, VanDen Berg D, Vanderstichele A, Wang Z, Webb PM, Wentzensen N, Werner HMJ, Winham SJ, Wolk A, Xia L, Xiang YB, Yang HP, Yu H, Zheng W, Zheng W, Pharoah PDP, Dunning AM, Kraft P, De Vivo I, Tomlinson I, Easton DF, Spurdle AB, Thompson DJ

Nature communications · 2018 · PMID 30093612 · open access

Questions about rs7981863

What is rs7981863?

rs7981863 is a single position in the genome, in or near the KLF5 gene. Published research associates it with endometrial cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7981863 linked to?

On MyGeneLog this position is linked to Endometrial Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs7981863 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7981863 come from?

GWAS Catalog, Nat Commun 2018, PMID:30093612. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Endometrial cancer (rs7981863). MyGeneLog™. https://www.mygenelog.com/variants/rs7981863

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