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Who was studied 75,638 European ancestry cases, 1,043,805 European ancestry controls.
The effect
Each copy of the G allele carried 1.05 times the odds of Alzheimer's disease or related dementias (95% confidence interval 1.03-1.06); p = 2 × 10−8.
How common The G allele had a frequency of about 22% in the people studied.
Where it sits Chromosome 12, band 12q23.3 — in an intron of RIC8B.
What each result means
A/ANo copy of the version the research linked to Alzheimer's disease or related dementias. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Alzheimer's disease or related dementias. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Alzheimer's disease or related dementias. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 42237039 · open access
Questions about rs7977765
What is rs7977765?
rs7977765 is a single position in the genome, in or near the RIC8B gene. Published research associates it with alzheimer's disease or related dementias. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7977765 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs7977765 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7977765 come from?
GWAS Catalog, Nature genetics 2026, PMID:42237039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Alzheimer's disease or related dementias (rs7977765). MyGeneLog™. https://www.mygenelog.com/variants/rs7977765