Standard

Migraine, familial hemiplegic, 3

SCN1A · rs797044985

Where this position leads

Strength of the evidence

2 / 4

ClinVar classifies it as disease-causing (or likely), reviewed at 1 of 4 stars.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Pathogenic; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2012-02-01. ClinVar record 208412 NM_001165963.4(SCN1A):c.2946+2T>G

Classification Pathogenic for Migraine, familial hemiplegic, 3; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2002-09-08. ClinVar record 1704264 NM_001165963.4(SCN1A):c.2946+2T>C

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A No copy of the version ClinVar lists as disease-causing for Migraine, familial hemiplegic, 3. This is the usual result. This call was sent to ClinVar without the lab's criteria, the least certain kind of record, so it may change. (ClinVar VCV001704264, no assertion criteria provided)

A/G One copy of the version ClinVar lists as disease-causing for Migraine, familial hemiplegic, 3. Some conditions need only one copy; for others, one copy makes a person a carrier who is usually healthy but can pass it on. A genetic counsellor can say which applies. This call was sent to ClinVar without the lab's criteria, the least certain kind of record, so it may change. (ClinVar VCV001704264, no assertion criteria provided)

G/G Two copies of the version ClinVar lists as disease-causing for Migraine, familial hemiplegic, 3. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. This call was sent to ClinVar without the lab's criteria, the least certain kind of record, so it may change. (ClinVar VCV001704264, no assertion criteria provided)

Source: ClinVar VCV001704264, no assertion criteria provided

Questions about rs797044985

What is rs797044985?

rs797044985 is a single position in the genome, in or near the SCN1A gene. Published research associates it with migraine, familial hemiplegic, 3. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs797044985 linked to?

On MyGeneLog this position is linked to Migraine. The research behind each link, and its sources, are set out on that condition page.

Does having rs797044985 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs797044985 come from?

ClinVar VCV001704264, no assertion criteria provided. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Migraine, familial hemiplegic, 3 (rs797044985). MyGeneLog™. https://www.mygenelog.com/variants/rs797044985

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