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Sensitive

Osteoarthritis (with total knee replacement)

near SENP1 · rs7967762

Where this position leads

Condition: Osteoarthritis

rs7967762 Condition: Osteoarthritis Osteoarthritis Condition rs7967762 rs7967762 near SENP1

What the study found

Who was studied 18,200 European ancestry cases, 233,841 European ancestry controls.

The effect Each copy of the T allele carried 1.11 times the odds of Osteoarthritis (with total knee replacement) (95% confidence interval 1.07386533-1.146066223); p = 4 × 10−10.

How common The T allele had a frequency of about 16% in the people studied.

Where it sits Chromosome 12, band 12q13.11 — between genes, 13.4 kb from SENP1.

What each result means

C/C No copy of the version the research linked to Osteoarthritis (with total knee replacement). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Osteoarthritis (with total knee replacement). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Osteoarthritis (with total knee replacement). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
Boer CG, Hatzikotoulas K, Southam L, Stefánsdóttir L, Zhang Y, Coutinho de Almeida R, Wu TT, Zheng J, Hartley A, Teder-Laving M, Skogholt AH, Terao C
and 50 more — show all
Zengini E, Alexiadis G, Barysenka A, Bjornsdottir G, Gabrielsen ME, Gilly A, Ingvarsson T, Johnsen MB, Jonsson H, Kloppenburg M, Luetge A, Lund SH, Mägi R, Mangino M, Nelissen RRGHH, Shivakumar M, Steinberg J, Takuwa H, Thomas LF, Tuerlings M, Babis GC, Cheung JPY, Kang JH, Kraft P, Lietman SA, Samartzis D, Slagboom PE, Stefansson K, Thorsteinsdottir U, Tobias JH, Uitterlinden AG, Winsvold B, Zwart JA, Davey Smith G, Sham PC, Thorleifsson G, Gaunt TR, Morris AP, Valdes AM, Tsezou A, Cheah KSE, Ikegawa S, Hveem K, Esko T, Wilkinson JM, Meulenbelt I, Lee MTM, van Meurs JBJ, Styrkársdóttir U, Zeggini E
arcOGEN Consortium · HUNT All-In Pain · ARGO Consortium · Regeneron Genetics Center
Cell · 2021 · PMID 34450027 · open access

Questions about rs7967762

What is rs7967762?

rs7967762 is a single position in the genome, in or near the near SENP1 gene. Published research associates it with osteoarthritis (with total knee replacement). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7967762 linked to?

On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs7967762 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7967762 come from?

GWAS Catalog, Cell 2021, PMID:34450027. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Osteoarthritis (with total knee replacement) (rs7967762). MyGeneLog™. https://www.mygenelog.com/variants/rs7967762

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