Gene Knowledge Graph
UTC
Standard

Left ventricular global circumferential strain

SERPINB9 · rs79567239

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 19,260 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.294 higher (95% confidence interval 0.2-0.39); p = 5 × 10−9.

How common The G allele had a frequency of about 11% in the people studied.

Where it sits Chromosome 6, band 6p25.2 — between genes, 5.4 kb from SERPINB9.

What each result means

G/G Two copies of the version the research linked to Left ventricular global circumferential strain. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Left ventricular global circumferential strain. That is a smaller link than two copies.
T/T No copy of the version the research linked to Left ventricular global circumferential strain. This is the starting point the study compared everyone against.
Source
Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect
Tadros R, Francis C, Xu X, Vermeer AMC, Harper AR, Huurman R, Kelu Bisabu K, Walsh R, Hoorntje ET, Te Rijdt WP, Buchan RJ, van Velzen HG
and 58 more — show all
van Slegtenhorst MA, Vermeulen JM, Offerhaus JA, Bai W, de Marvao A, Lahrouchi N, Beekman L, Karper JC, Veldink JH, Kayvanpour E, Pantazis A, Baksi AJ, Whiffin N, Mazzarotto F, Sloane G, Suzuki H, Schneider-Luftman D, Elliott P, Richard P, Ader F, Villard E, Lichtner P, Meitinger T, Tanck MWT, van Tintelen JP, Thain A, McCarty D, Hegele RA, Roberts JD, Amyot J, Dubé MP, Cadrin-Tourigny J, Giraldeau G, L'Allier PL, Garceau P, Tardif JC, Boekholdt SM, Lumbers RT, Asselbergs FW, Barton PJR, Cook SA, Prasad SK, O'Regan DP, van der Velden J, Verweij KJH, Talajic M, Lettre G, Pinto YM, Meder B, Charron P, de Boer RA, Christiaans I, Michels M, Wilde AAM, Watkins H, Matthews PM, Ware JS, Bezzina CR
Nature genetics · 2021 · PMID 33495596 · open access

Questions about rs79567239

What is rs79567239?

rs79567239 is a single position in the genome, in or near the SERPINB9 gene. Published research associates it with left ventricular global circumferential strain. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs79567239 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs79567239 come from?

GWAS Catalog, Nature genetics 2021, PMID:33495596. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Left ventricular global circumferential strain (rs79567239). MyGeneLog™. https://www.mygenelog.com/variants/rs79567239

← See all variants