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Who was studied 5,956 European ancestry cases, 14,927 European ancestry controls; replicated in 14,594 European ancestry cases, 26,715 European ancestry controls, 151 Iranian ancestry cases, 342 Iranian ancestry controls, 184 Indian ancestry cases, 990 Indian ancestry controls, 1,690 East Asian ancestry cases, 3,719 East Asian ancestry controls.
The effect
Each copy of the A allele carried 1.09 times the odds of Crohn's disease (95% confidence interval 1.06-1.11); p = 1 × 10−9.
How common The A allele had a frequency of about 33% in the people studied.
Where it sits Chromosome 12, band 12p13.31 — in an intron of SCNN1A.
What each result means
A/ATwo copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
rs7954567 is a single position in the genome, in or near the CD27 gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7954567 linked to?
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs7954567 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7954567 come from?
GWAS Catalog, Nat Genet 2015, PMID:26192919. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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