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Who was studied 380,287 European ancestry individuals; replicated in 4,089 European ancestry cases, 11,901 European ancestry controls, 44,848 cases, 1,571,864 controls.
The effect
Each copy of the T allele shifted the measure 0.112 lower (95% confidence interval 0.098-0.126); p = 4 × 10−54.
How common The T allele had a frequency of about 65% in the people studied.
Where it sits Chromosome 11, band 11q14.3 — between genes, 4.1 kb from NOX4.
What each result means
C/CNo copy of the version the research linked to Cutaneous melanoma (MTAG). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Cutaneous melanoma (MTAG). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Cutaneous melanoma (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
The Journal of investigative dermatology · 2022 · PMID 34813871
Questions about rs7943603
What is rs7943603?
rs7943603 is a single position in the genome, in or near the near NOX4 gene. Published research associates it with cutaneous melanoma (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7943603 linked to?
On MyGeneLog this position is linked to Cutaneous Malignant Melanoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs7943603 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7943603 come from?
GWAS Catalog, The Journal of investigative dermatology 2022, PMID:34813871. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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