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Bladder cancer

TNNT3 · rs7937265

Where this position leads

Condition: Bladder Cancer

rs7937265 Condition: Bladder Cancer Bladder Cancer Condition rs7937265 rs7937265 TNNT3

What the study found

Who was studied 1,055 African ancestry cases, 120,313 African ancestry controls, 1,259 East Asian ancestry cases, 105,581 East Asian ancestry controls, 30,156 European ancestry cases, 1,527,568 European ancestry controls.

The effect Each copy of the G allele carried 1.10 times the odds of Bladder cancer (95% confidence interval 1.07915245907951-1.12891384678149); p = 7 × 10−18.

How common The G allele had a frequency of about 19% in the people studied.

Where it sits Chromosome 11, band 11p15.5 — in an intron of TNNT3.

What ClinVar records

Classification Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2019-10-20. ClinVar record 1267001 NM_006757.4(TNNT3):c.68-125C>G

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C No copy of the version the research linked to Bladder cancer. This is the starting point the study compared everyone against.
C/G One copy of the version the research linked to Bladder cancer. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Bladder cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Multi-population GWAS meta-analysis identifies bladder cancer susceptibility loci and highlights genetic regulation of smoking-related risk
Prokunina-Olsson L, Florez-Vargas O, Levin MG, Dutta D, Breeze CE, Hurwitz LM, Yan W, Lamy P, Papenberg BW, Wang K, Lee CH, Milne RL
and 45 more — show all
Gu J, Um CY, Joseph V, Furberg H, Le Calvez-Kelm F, Lori A, Choudhury PP, Afshar N, Kogevinas M, Offit K, Vermeulen SH, López de Maturana E, Albanes D, Purdue MP, Cortessis VK, Karagas MR, Kooperberg C, Bjurlin M, Tadesse DA, Moore SC, Huang WY, Haiman CA, Stern MC, Eliassen AH, Mucci LA, Aben KK, Galesloot TE, Verma A, Yoshino S, Hikino K, Terao C, Rafnar T, Matsuda K, Shuin T, Garcia-Closas M, Real FX, Kiemeney LA, Chanock SJ, Malats N, Silverman DT, Dyrskjot L, Rothman N, Damrauer SM, Koutros S, Damrauer JS
UROMOL Consortium
Nature communications · 2026 · PMID 42706231 · open access

Questions about rs7937265

What is rs7937265?

rs7937265 is a single position in the genome, in or near the TNNT3 gene. Published research associates it with bladder cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7937265 linked to?

On MyGeneLog this position is linked to Bladder Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs7937265 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7937265 come from?

GWAS Catalog, Nature communications 2026, PMID:42706231. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Bladder cancer (rs7937265). MyGeneLog™. https://www.mygenelog.com/variants/rs7937265

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