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High density lipoprotein cholesterol levels

FADS2 · rs7935946

What the study found

Who was studied 313,372 European ancestry individuals, 5,573 African ancestry individuals, 6,689 South Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0463 lower (95% confidence interval 0.035-0.057); p = 4 × 10−16.

Where it sits Chromosome 11, band 11q12.2 — in an intron of FADS2.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of High density lipoprotein cholesterol levels — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with High density lipoprotein cholesterol levels.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of High density lipoprotein cholesterol levels compared to the general population.
Source

Questions about rs7935946

What is rs7935946?

rs7935946 is a single position in the genome, in or near the FADS2 gene. Published research associates it with high density lipoprotein cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7935946 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7935946 come from?

GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

High density lipoprotein cholesterol levels (rs7935946). MyGeneLog™. https://www.mygenelog.com/variants/rs7935946

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