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Atrial fibrillation

CMSS1 · rs793440

Where this position leads

What the study found

Who was studied 228,926 European ancestry cases, 1,611,415 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0242 lower (95% confidence interval 0.017-0.031); p = 1 × 10⁻¹⁰.

How common The T allele had a frequency of about 34% in the people studied.

Where it sits Chromosome 3, band 3q12.1 — a missense change in CMSS1.

What ClinVar records

Classification Benign for FILIP1L-related disorder; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2019-06-19. ClinVar record 3059252 NM_001387850.1(FILIP1L):c.503G>A (p.Arg168His)

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C No copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation

Yuan S, Chen J, Ruan X, Li Y, Abramowitz SA, Wang L, Jiang F, Xiong Y, Levin MG, Voight BF, Gill D, Burgess S

and 5 more — show all

Åkesson A, Michaëlsson K, Li X, Damrauer SM, Larsson SC

Nature communications · 2025 · PMID 40645996 · open access

Questions about rs793440

What is rs793440?

rs793440 is a single position in the genome, in or near the CMSS1 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs793440 linked to?

On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.

Does having rs793440 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs793440 come from?

GWAS Catalog, Nature communications 2025, PMID:40645996. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Atrial fibrillation (rs793440). MyGeneLog™. https://www.mygenelog.com/variants/rs793440

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