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Inguinal hernia

near WT1 · rs7924571

Where this position leads

Condition: Inguinal Hernia

rs7924571 Condition: Inguinal Hernia Inguinal Hernia Condition rs7924571 rs7924571 near WT1

What the study found

Who was studied 33,379 European ancestry cases, 436,717 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0745 lower (95% confidence interval 0.054-0.095); p = 6 × 10−13.

Where it sits Chromosome 11, band 11p13 — between genes, 59.3 kb from WT1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Inguinal hernia compared to the general population.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Inguinal hernia.
C/C Published research associates this genotype with typical/baseline likelihood of Inguinal hernia — no copies of the reported risk allele.
Source
Ancestry- and sex-specific effects underlying inguinal hernia susceptibility identified in a multiethnic genome-wide association study meta-analysis
Choquet H, Li W, Yin J, Bradley R, Hoffmann TJ, Nandakumar P, Mostaedi R, Tian C, Ahituv N, Jorgenson E
23 and Me Research Team
Human molecular genetics · 2022 · PMID 35022708 · open access

Questions about rs7924571

What is rs7924571?

rs7924571 is a single position in the genome, in or near the near WT1 gene. Published research associates it with inguinal hernia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7924571 linked to?

On MyGeneLog this position is linked to Inguinal Hernia. The research behind each link, and its sources, are set out on that condition page.

Does having rs7924571 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7924571 come from?

GWAS Catalog, Human molecular genetics 2022, PMID:35022708. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Inguinal hernia (rs7924571). MyGeneLog™. https://www.mygenelog.com/variants/rs7924571

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