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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied up to 53,293 European ancestry Attention-deficit/hyperactivity disorder individuals, up to 164,684 European ancestry problematic alcohol use individuals, up to 186,875 European ancestry lifetime cannabis use individuals, up to 357,187 European ancestry individuals measuring reverse-coded age at first sexual intercourse, up to 336,121 European ancestry individuals measuring number of sexual partners, up to 426,379 European ancestry individuals measuring general risk tolerance, up to 1,251,809 European ancestry individuals measuring lifetime smoking initiation.
The effect
Each copy of the G allele shifted the measure 0.008 lower (95% confidence interval 0.006-0.01); p = 2 × 10−10.
How common The G allele had a frequency of about 40% in the people studied.
Where it sits Chromosome 10, band 10q22.1 — in an intron of CDH23.
What each result means
A/ANo copy of the version the research linked to Externalizing behaviour (multivariate analysis). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Externalizing behaviour (multivariate analysis). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Externalizing behaviour (multivariate analysis). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature neuroscience · 2021 · PMID 34446935 · open access
Questions about rs7923245
What is rs7923245?
rs7923245 is a single position in the genome, in or near the CDH23 gene. Published research associates it with externalizing behaviour (multivariate analysis). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs7923245 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7923245 come from?
GWAS Catalog, Nature neuroscience 2021, PMID:34446935. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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