Alzheimer's disease, proxy Alzheimer's disease or related dementias
USP6NL · rs7921833
0 24127239Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI2Microsoft · Copilot7Amazon2Apple3China (ByteDance, Huawei, Baidu…)0Others9Total24Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 128,681 European ancestry cases, 849,833 European ancestry controls.
The effect
Each copy of the A allele carried 0.95 times the odds of Alzheimer's disease, proxy Alzheimer's disease or related dementias (95% confidence interval 0.94-0.96); p = 3 × 10−11.
How common The A allele had a frequency of about 21% in the people studied.
Where it sits Chromosome 10, band 10p14 — in an intron of USP6NL.
What each result means
A/ATwo copies of the version the research linked to Alzheimer's disease, proxy Alzheimer's disease or related dementias. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Alzheimer's disease, proxy Alzheimer's disease or related dementias. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Alzheimer's disease, proxy Alzheimer's disease or related dementias. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 42237039 · open access
Questions about rs7921833
What is rs7921833?
rs7921833 is a single position in the genome, in or near the USP6NL gene. Published research associates it with alzheimer's disease, proxy alzheimer's disease or related dementias. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7921833 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs7921833 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7921833 come from?
GWAS Catalog, Nature genetics 2026, PMID:42237039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 24127239Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI2Microsoft · Copilot7Amazon2Apple3China (ByteDance, Huawei, Baidu…)0Others9Total24Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Alzheimer's disease, proxy Alzheimer's disease or related dementias (rs7921833). MyGeneLog™. https://www.mygenelog.com/variants/rs7921833