Sensitive

Alzheimer's disease (age of onset)

near ECHDC3 · rs7920721

Where this position leads

Condition: Alzheimer's Disease

rs7920721 Condition: Alzheimer's Disease Alzheimer's Disease Condition rs7920721 rs7920721 near ECHDC3

What the study found

Who was studied 27,993 European ancestry individuals, 6,949 Black individuals, 6,530 Hispanic individuals, 55 individuals.

The effect Each copy of the G allele shifted the measure 0.031 higher (95% confidence interval 0.021-0.041); p = 9 × 10−9.

How common The G allele had a frequency of about 36% in the people studied.

Where it sits Chromosome 10, band 10p14 — between genes, 64.1 kb from ECHDC3.

What each result means

A/A No copy of the version the research linked to Alzheimer's disease (age of onset). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Alzheimer's disease (age of onset). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Alzheimer's disease (age of onset). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs7920721

What is rs7920721?

rs7920721 is a single position in the genome, in or near the near ECHDC3 gene. Published research associates it with alzheimer's disease (age of onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7920721 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs7920721 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7920721 come from?

GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2025, PMID:40883957. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alzheimer's disease (age of onset) (rs7920721). MyGeneLog™. https://www.mygenelog.com/variants/rs7920721

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