FTO · rs79206939
Where this position leads
Condition: Inflammatory Bowel Disease
What the study found
Who was studied 113 Korean ancestry cases, 154 Korean ancestry controls; replicated in 245 East Asian ancestry cases, 522 East Asian ancestry controls.
The effect Each copy of the A allele carried 4.30 times the odds of Thiopurine-induced leukopenia in inflammatory bowel disease (95% confidence interval 2.50-7.40); p = 1 × 10−8.
How common The A allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 16, band 16q12.2 — a missense change in FTO.
What ClinVar records
Classification
Benign for Lethal polymalformative syndrome, Boissel type; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2025-12-06.
ClinVar record 319681 NM_001080432.3(FTO):c.400G>A (p.Ala134Thr)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs79206939 is a single position in the genome, in or near the FTO gene. Published research associates it with thiopurine-induced leukopenia in inflammatory bowel disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Inflammatory Bowel Disease. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Gut 2016, PMID:27558924. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Thiopurine-induced leukopenia in inflammatory bowel disease (rs79206939). MyGeneLog™. https://www.mygenelog.com/variants/rs79206939