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Who was studied 33 Japanese ancestry cases, 6,270 East Asian ancestry controls; replicated in 21 European ancestry cases, 84 European ancestry controls.
The effect
Each copy of the A allele carried 3.87 times the odds of Clinically amyopathic dermatomyositis (95% confidence interval 2.33-6.55); p = 2 × 10−8.
How common The A allele had a frequency of about 13% in the people studied.
Where it sits Chromosome 10, band 10q11.23 — in an intron of WDFY4.
What each result means
A/ATwo copies of the version the research linked to Clinically amyopathic dermatomyositis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Clinically amyopathic dermatomyositis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Clinically amyopathic dermatomyositis. This is the starting point the study compared everyone against.
Annals of the rheumatic diseases · 2018 · PMID 29331962
Questions about rs7919656
What is rs7919656?
rs7919656 is a single position in the genome, in or near the WDFY4 gene. Published research associates it with clinically amyopathic dermatomyositis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7919656 linked to?
On MyGeneLog this position is linked to Myositis. The research behind each link, and its sources, are set out on that condition page.
Does having rs7919656 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7919656 come from?
GWAS Catalog, Ann Rheum Dis 2018, PMID:29331962. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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