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Who was studied 3,504 European ancestry cases, 861,198 European ancestry controls.
The effect
Each copy of the C allele carried 0.83 times the odds of Otosclerosis (95% confidence interval 0.8-0.88); p = 1 × 10−13.
How common The C allele had a frequency of about 50% in the people studied.
Where it sits Chromosome 6, band 6p21.31 — in an intron of IP6K3.
What each result means
C/CTwo copies of the version the research linked to Otosclerosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Otosclerosis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Otosclerosis. This is the starting point the study compared everyone against.
Nature communications · 2023 · PMID 36653343 · open access
Questions about rs791903
What is rs791903?
rs791903 is a single position in the genome, in or near the IP6K3 gene. Published research associates it with otosclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs791903 linked to?
On MyGeneLog this position is linked to Otosclerosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs791903 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs791903 come from?
GWAS Catalog, Nature communications 2023, PMID:36653343. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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