Standard

circulating leptin levels adjusted for BMI

LEP · rs791600

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 56,708 European ancestry, African American or Afro-Caribbean, East Asian ancestry, Hispanic or Latin American individuals.

The effect Each copy of the A allele shifted the measure 0.066 lower (95% confidence interval 0.052-0.08); p = 1 × 10⁻²³.

How common The A allele had a frequency of about 42% in the people studied.

Where it sits Chromosome 7, band 7q32.1 — between genes, 15.5 kb from LEP.

What each result means

A/A Two copies of the version the research linked to circulating leptin levels adjusted for BMI. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to circulating leptin levels adjusted for BMI. That is a smaller link than two copies.

G/G No copy of the version the research linked to circulating leptin levels adjusted for BMI. This is the starting point the study compared everyone against.

Source

Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity

Yaghootkar H, Zhang Y, Spracklen CN, Karaderi T, Huang LO, Bradfield J, Schurmann C, Fine RS, Preuss MH, Kutalik Z, Wittemans LBL, Lu Y

and 104 more — show all

Metz S, Willems SM, Li-Gao R, Grarup N, Wang S, Molnos S, Sandoval-Zárate AA, Nalls MA, Lange LA, Haesser J, Guo X, Lyytikäinen LP, Feitosa MF, Sitlani CM, Venturini C, Mahajan A, Kacprowski T, Wang CA, Chasman DI, Amin N, Broer L, Robertson N, Young KL, Allison M, Auer PL, Blüher M, Borja JB, Bork-Jensen J, Carrasquilla GD, Christofidou P, Demirkan A, Doege CA, Garcia ME, Graff M, Guo K, Hakonarson H, Hong J, Ida Chen YD, Jackson R, Jakupović H, Jousilahti P, Justice AE, Kähönen M, Kizer JR, Kriebel J, LeDuc CA, Li J, Lind L, Luan J, Mackey DA, Mangino M, Männistö S, Martin Carli JF, Medina-Gomez C, Mook-Kanamori DO, Morris AP, de Mutsert R, Nauck M, Prokic I, Pennell CE, Pradhan AD, Psaty BM, Raitakari OT, Scott RA, Skaaby T, Strauch K, Taylor KD, Teumer A, Uitterlinden AG, Wu Y, Yao J, Walker M, North KE, Kovacs P, Ikram MA, van Duijn CM, Ridker PM, Lye S, Homuth G, Ingelsson E, Spector TD, McKnight B, Province MA, Lehtimäki T, Adair LS, Rotter JI, Reiner AP, Wilson JG, Harris TB, Ripatti S, Grallert H, Meigs JB, Salomaa V, Hansen T, Willems van Dijk K, Wareham NJ, Grant SFA, Langenberg C, Frayling TM, Lindgren CM, Mohlke KL, Leibel RL, Loos RJF, Kilpeläinen TO

Diabetes · 2020 · PMID 32917775

Questions about rs791600

What is rs791600?

rs791600 is a single position in the genome, in or near the LEP gene. Published research associates it with circulating leptin levels adjusted for bmi. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs791600 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs791600 come from?

GWAS Catalog, Diabetes 2020, PMID:32917775. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

circulating leptin levels adjusted for BMI (rs791600). MyGeneLog™. https://www.mygenelog.com/variants/rs791600

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