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Who was studied 168,363 European ancestry cases, 1,725,558 European ancestry controls, 21,202 African ancestry cases, 121,670 African ancestry controls, 12,665 East Asian ancestry cases, 245,263 East Asian ancestry controls, 5,116 Hispanic or Latin American cases, 58,719 Hispanic or Latin American controls.
The effect
Each copy of the C allele shifted the measure 0.0367 lower (95% confidence interval 0.026-0.048); p = 6 × 10−11.
How common The C allele had a frequency of about 88% in the people studied.
Where it sits Chromosome 10, band 10q24.32 — in an intron of SUFU.
What each result means
C/CTwo copies of the version the research linked to Heart failure. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Heart failure. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Heart failure. This is the starting point the study compared everyone against.
rs79159857 is a single position in the genome, in or near the SUFU gene. Published research associates it with heart failure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs79159857 linked to?
On MyGeneLog this position is linked to Heart Failure. The research behind each link, and its sources, are set out on that condition page.
Does having rs79159857 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs79159857 come from?
GWAS Catalog, Nature genetics 2025, PMID:40195560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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