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Clopidogrel active metabolite levels

CYP2C19 · rs7915414

Where this position leads

Drugs: Brivaracetam, Clopidogrel, Proton pump inhibitors, Serotonin reuptake antidepressants, Voriconazole

rs7915414 Drug: Brivaracetam Brivaracetam Drug Drug: Clopidogrel Clopidogrel Drug Drug: Proton pump inhibitors Proton pump inhibitors Drug Drug: Serotonin reuptake antidepressants Serotonin reuptake antidepressants Drug Drug: Voriconazole Voriconazole Drug rs7915414 rs7915414 CYP2C19

What the study found

Who was studied 513 Amish individuals.

The effect Each copy of the A allele shifted the measure 6.01 lower; p = 3 × 10−14.

How common The A allele had a frequency of about 20% in the people studied.

Where it sits Chromosome 10, band 10q23.33 — in an intron of CYP2C19.

What each result means

A/A Two copies of the version the research linked to Clopidogrel active metabolite levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Clopidogrel active metabolite levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Clopidogrel active metabolite levels. This is the starting point the study compared everyone against.
Source

Questions about rs7915414

What is rs7915414?

rs7915414 is a single position in the genome, in or near the CYP2C19 gene. Published research associates it with clopidogrel active metabolite levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs7915414 affect how medicines work?

CYP2C19 carries pharmacogenomic findings for Brivaracetam, Clopidogrel, Proton pump inhibitors, Serotonin reuptake antidepressants, Voriconazole. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs7915414 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7915414 come from?

GWAS Catalog, Pharmacogenetics and genomics 2017, PMID:28207573. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Clopidogrel active metabolite levels (rs7915414). MyGeneLog™. https://www.mygenelog.com/variants/rs7915414

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