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Diastolic blood pressure

CCDC141 · rs79146658

Where this position leads

Condition: Blood Pressure

rs79146658 Condition: Blood Pressure Blood Pressure Condition rs79146658 rs79146658 CCDC141

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Diastolic blood pressure — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Diastolic blood pressure.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Diastolic blood pressure compared to the general population.
Source
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P, Liu C, Cook JP, Kraja AT, Drenos F
and 47 more — show all
Loh M, Verweij N, Marten J, Karaman I, Lepe MP, O'Reilly PF, Knight J, Snieder H, Kato N, He J, Tai ES, Said MA, Porteous D, Alver M, Poulter N, Farrall M, Gansevoort RT, Padmanabhan S, Mägi R, Stanton A, Connell J, Bakker SJ, Metspalu A, Shields DC, Thom S, Brown M, Sever P, Esko T, Hayward C, van der Harst P, Saleheen D, Chowdhury R, Chambers JC, Chasman DI, Chakravarti A, Newton-Cheh C, Lindgren CM, Levy D, Kooner JS, Keavney B, Tomaszewski M, Samani NJ, Howson JM, Tobin MD, Munroe PB, Ehret GB, Wain LV
International Consortium of Blood Pressure (ICBP) 1000G Analyses · BIOS Consortium · Lifelines Cohort Study · Understanding Society Scientific group · CHD Exome+ Consortium · ExomeBP Consortium · T2D-GENES Consortium · GoT2DGenes Consortium · Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium · International Genomics of Blood Pressure (iGEN-BP) Consortium · UK Biobank CardioMetabolic Consortium BP working group
Nature genetics · 2017 · PMID 28135244 · open access

Questions about rs79146658

What is rs79146658?

rs79146658 is a single position in the genome, in or near the CCDC141 gene. Published research associates it with diastolic blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs79146658 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs79146658 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs79146658 come from?

GWAS Catalog, Nat Genet 2017, PMID:28135244. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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