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Steroid induced osteonecrosis of the femoral head and systemic lupus erythematosus

FRMD4A · rs7911501

Where this position leads

Condition: Systemic Lupus Erythematosus

rs7911501 Condition: Systemic Lupus Erythematosus Systemic Lupus Erythematosus Condition rs7911501 rs7911501 FRMD4A

What the study found

Who was studied 784 East Asian ancestry cases, 132,603 East Asian ancestry controls.

The effect Each copy of the A allele carried 1.99 times the odds of Steroid induced osteonecrosis of the femoral head and systemic lupus erythematosus (95% confidence interval 1.59-2.48); p = 1 × 10−9.

How common The A allele had a frequency of about 3% in the people studied.

Where it sits Chromosome 10, band 10p13 — inside FRMD4A.

What each result means

A/A Two copies of the version the research linked to Steroid induced osteonecrosis of the femoral head and systemic lupus erythematosus. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Steroid induced osteonecrosis of the femoral head and systemic lupus erythematosus. That is a smaller link than two copies.
G/G No copy of the version the research linked to Steroid induced osteonecrosis of the femoral head and systemic lupus erythematosus. This is the starting point the study compared everyone against.
Source
Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus
Suetsugu H, Kim K, Yamamoto T, Bang SY, Sakamoto Y, Shin JM, Sugano N, Kim JS, Mukai M, Lee YK, Ohmura K, Park DJ
and 43 more — show all
Takahashi D, Ahn GY, Karino K, Kwon YC, Miyamura T, Kim J, Nakamura J, Motomura G, Kuroda T, Niiro H, Miyamoto T, Takeuchi T, Ikari K, Amano K, Tada Y, Yamaji K, Shimizu M, Atsumi T, Seki T, Tanaka Y, Kubo T, Hisada R, Yoshioka T, Yamazaki M, Kabata T, Kajino T, Ohta Y, Okawa T, Naito Y, Kaneuji A, Yasunaga Y, Ohzono K, Tomizuka K, Koido M, Matsuda K, Okada Y, Suzuki A, Kim BJ, Kochi Y, Lee HS, Ikegawa S, Bae SC, Terao C
Human molecular genetics · 2022 · PMID 34850884

Questions about rs7911501

What is rs7911501?

rs7911501 is a single position in the genome, in or near the FRMD4A gene. Published research associates it with steroid induced osteonecrosis of the femoral head and systemic lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7911501 linked to?

On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs7911501 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7911501 come from?

GWAS Catalog, Human molecular genetics 2022, PMID:34850884. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Steroid induced osteonecrosis of the femoral head and systemic lupus erythematosus (rs7911501). MyGeneLog™. https://www.mygenelog.com/variants/rs7911501

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