DNA-incorporated thioguanine levels in 6-mercaptopurine-treated acute lymphoblastic leukaemia
TPMT · rs79050301
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Who was studied 443 European ancestry individuals.
The effect
The reported allele is C; the catalogue records no effect size
; p = 8 × 10−10.
Where it sits Chromosome 6, band 6p22.3 — in an intron of TPMT.
What each result means
C/CTwo copies of the version the research linked to DNA-incorporated thioguanine levels in 6-mercaptopurine-treated acute lymphoblastic leukaemia. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to DNA-incorporated thioguanine levels in 6-mercaptopurine-treated acute lymphoblastic leukaemia. That is a smaller link than two copies.
T/TNo copy of the version the research linked to DNA-incorporated thioguanine levels in 6-mercaptopurine-treated acute lymphoblastic leukaemia. This is the starting point the study compared everyone against.
rs79050301 is a single position in the genome, in or near the TPMT gene. Published research associates it with dna-incorporated thioguanine levels in 6-mercaptopurine-treated acute lymphoblastic leukaemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs79050301 affect how medicines work?
TPMT carries pharmacogenomic findings for Thiopurines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs79050301 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs79050301 come from?
GWAS Catalog, Leukemia 2018, PMID:30201983. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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