Sensitive

Schizophrenia

SORCS3 · rs7900775

Where this position leads

Condition: Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk)

rs7900775 Condition: Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk) Autism Spectrum Disorder and Schizo… Condition rs7900775 rs7900775 SORCS3

What the study found

Who was studied 53,386 European ancestry cases, 77,258 European ancestry controls, 14,004 East Asian ancestry cases, 16,757 East Asian ancestry controls, 6,152 African American cases, 3,918 African American controls, 1,234 Latino cases, 3,090 Latino controls; replicated in 1,979 European ancestry cases, 142,626 European ancestry controls.

The effect Each copy of the T allele carried 1.05 times the odds of Schizophrenia (95% confidence interval 1.03-1.06); p = 6 × 10−10.

How common The T allele had a frequency of about 33% in the people studied.

Where it sits Chromosome 10, band 10q25.1 — in an intron of SORCS3.

What each result means

C/C No copy of the version the research linked to Schizophrenia. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Schizophrenia. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Schizophrenia. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs7900775

What is rs7900775?

rs7900775 is a single position in the genome, in or near the SORCS3 gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7900775 linked to?

On MyGeneLog this position is linked to Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk). The research behind each link, and its sources, are set out on that condition page.

Does having rs7900775 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7900775 come from?

GWAS Catalog, Nature 2022, PMID:35396580. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Schizophrenia (rs7900775). MyGeneLog™. https://www.mygenelog.com/variants/rs7900775

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