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Low-density lipoprotein levels

PLA2G12B · rs7898735

What the study found

Who was studied 153,950 Korean ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0665 lower (95% confidence interval 0.058-0.075); p = 6 × 10−55.

How common The C allele had a frequency of about 24% in the people studied.

Where it sits Chromosome 10, band 10q22.1 — in an intron of PLA2G12B.

What each result means

C/C Two copies of the version the research linked to Low-density lipoprotein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Low-density lipoprotein levels. That is a smaller link than two copies.
T/T No copy of the version the research linked to Low-density lipoprotein levels. This is the starting point the study compared everyone against.
Source

Questions about rs7898735

What is rs7898735?

rs7898735 is a single position in the genome, in or near the PLA2G12B gene. Published research associates it with low-density lipoprotein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7898735 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7898735 come from?

GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Low-density lipoprotein levels (rs7898735). MyGeneLog™. https://www.mygenelog.com/variants/rs7898735

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