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Atopic dermatitis

S100A11 · rs78914480

Where this position leads

Condition: Atopic Dermatitis

rs78914480 Condition: Atopic Dermatitis Atopic Dermatitis Condition rs78914480 rs78914480 S100A11

What the study found

Who was studied 2,385 Japanese ancestry cases, 209,651 Japanese ancestry controls.

The effect Each copy of the A allele carried 2.40 times the odds of Atopic dermatitis (95% confidence interval 1.843869165-3.124573471); p = 8 × 10−11.

How common The A allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 1, band 1q21.3 — in an intron of S100A11.

What each result means

A/A Two copies of the version the research linked to Atopic dermatitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Atopic dermatitis. That is a smaller link than two copies.
G/G No copy of the version the research linked to Atopic dermatitis. This is the starting point the study compared everyone against.
Source
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T
and 77 more — show all
Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M, Kamatani Y
Nature genetics · 2020 · PMID 32514122

Questions about rs78914480

What is rs78914480?

rs78914480 is a single position in the genome, in or near the S100A11 gene. Published research associates it with atopic dermatitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs78914480 linked to?

On MyGeneLog this position is linked to Atopic Dermatitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs78914480 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs78914480 come from?

GWAS Catalog, Nature genetics 2020, PMID:32514122. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Atopic dermatitis (rs78914480). MyGeneLog™. https://www.mygenelog.com/variants/rs78914480

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