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Schizophrenia

ACADS · rs78885399

Where this position leads

Condition: Schizophrenia

rs78885399 Condition: Schizophrenia Schizophrenia Condition rs78885399 rs78885399 ACADS

What the study found

Who was studied 1,940 Japanese ancestry cases, 7,408 Japanese ancestry controls; replicated in 4,071 Japanese ancestry cases, 54,470 Japanese ancestry controls.

The effect Each copy of the C allele carried 1.15 times the odds of Schizophrenia (95% confidence interval 1.09-1.22); p = 1 × 10−8.

Where it sits Chromosome 12, band 12q24.31 — between genes, 1.1 kb from ACADS.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Schizophrenia compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Schizophrenia.
T/T Published research associates this genotype with typical/baseline likelihood of Schizophrenia — no copies of the reported risk allele.
Source
Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect
Ikeda M, Takahashi A, Kamatani Y, Momozawa Y, Saito T, Kondo K, Shimasaki A, Kawase K, Sakusabe T, Iwayama Y, Toyota T, Wakuda T
and 20 more — show all
Kikuchi M, Kanahara N, Yamamori H, Yasuda Y, Watanabe Y, Hoya S, Aleksic B, Kushima I, Arai H, Takaki M, Hattori K, Kunugi H, Okahisa Y, Ohnuma T, Ozaki N, Someya T, Hashimoto R, Yoshikawa T, Kubo M, Iwata N
Schizophrenia bulletin · 2019 · PMID 30285260

Questions about rs78885399

What is rs78885399?

rs78885399 is a single position in the genome, in or near the ACADS gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs78885399 linked to?

On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.

Does having rs78885399 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs78885399 come from?

GWAS Catalog, Schizophr Bull 2018, PMID:30285260. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Schizophrenia (rs78885399). MyGeneLog™. https://www.mygenelog.com/variants/rs78885399

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