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Who was studied 168,363 European ancestry cases, 1,725,558 European ancestry controls, 21,202 African ancestry cases, 121,670 African ancestry controls, 12,665 East Asian ancestry cases, 245,263 East Asian ancestry controls, 5,116 Hispanic or Latin American cases, 58,719 Hispanic or Latin American controls.
The effect
Each copy of the A allele shifted the measure 0.0237 higher (95% confidence interval 0.017-0.031); p = 4 × 10−11.
How common The A allele had a frequency of about 57% in the people studied.
Where it sits Chromosome 9, band 9q31.3 — in an intron of TMEM245.
What each result means
A/ATwo copies of the version the research linked to Heart failure. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Heart failure. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Heart failure. This is the starting point the study compared everyone against.
rs7873569 is a single position in the genome, in or near the TMEM245 gene. Published research associates it with heart failure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7873569 linked to?
On MyGeneLog this position is linked to Heart Failure. The research behind each link, and its sources, are set out on that condition page.
Does having rs7873569 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7873569 come from?
GWAS Catalog, Nature genetics 2025, PMID:40195560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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