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Lung function (FEV1)

GLIS3 · rs7872188

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 48,943 European ancestry individuals.; replicated in 57,176 European ancestry individuals, 38,199 individuals..

The effect Each copy of the T allele shifted the measure 0.026 lower (95% confidence interval 0.018-0.034); p = 2 × 10⁻¹⁰.

How common The T allele had a frequency of about 40% in the people studied.

Where it sits Chromosome 9, band 9p24.2 — in an intron of GLIS3.

What each result means

C/C No copy of the version the research linked to Lung function (FEV1). This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Lung function (FEV1). That is a smaller link than two copies.

T/T Two copies of the version the research linked to Lung function (FEV1). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

Wain LV, Shrine N, Artigas MS, Erzurumluoglu AM, Noyvert B, Bossini-Castillo L, Obeidat M, Henry AP, Portelli MA, Hall RJ, Billington CK, Rimington TL

and 94 more — show all

Fenech AG, John C, Blake T, Jackson VE, Allen RJ, Prins BP, Campbell A, Porteous DJ, Jarvelin MR, Wielscher M, James AL, Hui J, Wareham NJ, Zhao JH, Wilson JF, Joshi PK, Stubbe B, Rawal R, Schulz H, Imboden M, Probst-Hensch NM, Karrasch S, Gieger C, Deary IJ, Harris SE, Marten J, Rudan I, Enroth S, Gyllensten U, Kerr SM, Polasek O, Kähönen M, Surakka I, Vitart V, Hayward C, Lehtimäki T, Raitakari OT, Evans DM, Henderson AJ, Pennell CE, Wang CA, Sly PD, Wan ES, Busch R, Hobbs BD, Litonjua AA, Sparrow DW, Gulsvik A, Bakke PS, Crapo JD, Beaty TH, Hansel NN, Mathias RA, Ruczinski I, Barnes KC, Bossé Y, Joubert P, van den Berge M, Brandsma CA, Paré PD, Sin DD, Nickle DC, Hao K, Gottesman O, Dewey FE, Bruse SE, Carey DJ, Kirchner HL, Jonsson S, Thorleifsson G, Jonsdottir I, Gislason T, Stefansson K, Schurmann C, Nadkarni G, Bottinger EP, Loos RJ, Walters RG, Chen Z, Millwood IY, Vaucher J, Kurmi OP, Li L, Hansell AL, Brightling C, Zeggini E, Cho MH, Silverman EK, Sayers I, Trynka G, Morris AP, Strachan DP, Hall IP, Tobin MD

Understanding Society Scientific Group · Geisinger-Regeneron DiscovEHR Collaboration

Nature genetics · 2017 · PMID 28166213 · open access

Questions about rs7872188

What is rs7872188?

rs7872188 is a single position in the genome, in or near the GLIS3 gene. Published research associates it with lung function (fev1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7872188 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7872188 come from?

GWAS Catalog, Nature genetics 2017, PMID:28166213. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Lung function (FEV1) (rs7872188). MyGeneLog™. https://www.mygenelog.com/variants/rs7872188

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