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Weight

PAPPA · rs7869550

Where this position leads

Conditions: Obesity and Body Weight, Osteoarthritis

rs7869550 Condition: Obesity and Body Weight Obesity and Body Weight Condition Condition: Osteoarthritis Osteoarthritis Condition rs7869550 rs7869550 PAPPA

What the study found

Who was studied 507,850 East Asian ancestry individuals, 420,829 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.026 higher (95% confidence interval 0.02-0.032); p = 1 × 10−19.

Where it sits Chromosome 9, band 9q33.1 — in an intron of PAPPA.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Weight compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Weight.
G/G Published research associates this genotype with typical/baseline likelihood of Weight — no copies of the reported risk allele.
Source
Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures
Jee YH, Wang Y, Jung KJ, Lee JY, Kimm H, Duan R, Price AL, Martin AR, Kraft P
Nature communications · 2025 · PMID 40436827 · open access

Questions about rs7869550

What is rs7869550?

rs7869550 is a single position in the genome, in or near the PAPPA gene. Published research associates it with weight. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7869550 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight, Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs7869550 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7869550 come from?

GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Weight (rs7869550). MyGeneLog™. https://www.mygenelog.com/variants/rs7869550

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