Sensitive

Tourette syndrome

COL27A1 · rs7868992

Where this position leads

What the study found

Who was studied 778 European ancestry cases, 4,414 European ancestry controls, 242 Ashkenazi Jewish cases, 354 Ashkenazi Jewish controls, 265 French Canadian founder cases, 196 French Canadian founder controls; replicated in 211 Latin American cases, 285 Latin American controls.

The effect Each copy of the G allele carried 1.29 times the odds of Tourette syndrome; p = 3 × 10⁻⁸.

How common The G allele had a frequency of about 28% in the people studied.

Where it sits Chromosome 9, band 9q32 — in an intron of COL27A1.

What each result means

A/A No copy of the version the research linked to Tourette syndrome. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Tourette syndrome. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Tourette syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association study of Tourette's syndrome

Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, Osiecki L

and 86 more — show all

Illmann C, Pluzhnikov A, Konkashbaev A, Davis LK, Han B, Crane J, Moorjani P, Crenshaw AT, Parkin MA, Reus VI, Lowe TL, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath DC, Smit JH, King RA, Fernandez TV, Leckman JF, Kidd KK, Kidd JR, Pakstis AJ, State MW, Herrera LD, Romero R, Fournier E, Sandor P, Barr CL, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman CL, Bruun RD, Erenberg G, Naarden AL, Lee PC, Weiss N, Kremeyer B, Berrío GB, Campbell DD, Cardona Silgado JC, Ochoa WC, Mesa Restrepo SC, Muller H, Valencia Duarte AV, Lyon GJ, Leppert M, Morgan J, Weiss R, Grados MA, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield JA, Heiman GA, Gilbert DL, Hoekstra PJ, Robertson MM, Kurlan R, Liu C, Gibbs JR, Singleton A, Hardy J, Strengman E, Ophoff RA, Wagner M, Moessner R, Mirel DB, Posthuma D, Sabatti C, Eskin E, Conti DV, Knowles JA, Ruiz-Linares A, Rouleau GA, Purcell S, Heutink P, Oostra BA, McMahon WM, Freimer NB, Cox NJ, Pauls DL

North American Brain Expression Consortium · UK Human Brain Expression Database

Molecular psychiatry · 2013 · PMID 22889924 · open access

Questions about rs7868992

What is rs7868992?

rs7868992 is a single position in the genome, in or near the COL27A1 gene. Published research associates it with tourette syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7868992 linked to?

On MyGeneLog this position is linked to Tourette Syndrome. The research behind each link, and its sources, are set out on that condition page.

Does having rs7868992 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7868992 come from?

GWAS Catalog, Mol Psychiatry 2012, PMID:22889924. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Tourette syndrome (rs7868992). MyGeneLog™. https://www.mygenelog.com/variants/rs7868992

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