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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 4,759 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 1.7 lower (95% confidence interval 1.33-2.06); p = 1 × 10−19.
How common The T allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 7, band 7q22.1 — in an intron of KPNA7.
What each result means
G/GNo copy of the version the research linked to Blood 5alpha-androstan-3alpha,17alpha-diol monosulfate levels. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Blood 5alpha-androstan-3alpha,17alpha-diol monosulfate levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Blood 5alpha-androstan-3alpha,17alpha-diol monosulfate levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Genome biology · 2026 · PMID 42426908 · open access
Questions about rs78653058
What is rs78653058?
rs78653058 is a single position in the genome, in or near the KPNA7 gene. Published research associates it with blood 5alpha-androstan-3alpha,17alpha-diol monosulfate levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs78653058 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs78653058 come from?
GWAS Catalog, Genome biology 2026, PMID:42426908. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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