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Sensitive

Type 2 diabetes

IDE · rs78627331

Where this position leads

Condition: Type 2 Diabetes

rs78627331 Condition: Type 2 Diabetes Type 2 Diabetes Condition rs78627331 rs78627331 IDE

What the study found

Who was studied 15,463 Japanese ancestry cases, 26,183 Japanese ancestry controls; replicated in 20,490 East Asian ancestry cases, 22,922 East Asian ancestry controls, 38,947 European ancestry cases, 121,903 European ancestry controls, 10,587 South Asian ancestry cases, 14,378 South Asian ancestry controls, 3,848 Mexican/Latino cases, 4,366 Mexican/Latino controls.

The effect Each copy of the C allele carried 1.33 times the odds of Type 2 diabetes (95% confidence interval 1.24-1.44); p = 2 × 10−14.

How common The C allele had a frequency of about 3% in the people studied.

Where it sits Chromosome 10, band 10q23.33 — in an intron of EXOC6.

What each result means

A/A No copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
A/C One copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
C/C Two copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes
Imamura M, Takahashi A, Yamauchi T, Hara K, Yasuda K, Grarup N, Zhao W, Wang X, Huerta-Chagoya A, Hu C, Moon S, Long J
and 52 more — show all
Kwak SH, Rasheed A, Saxena R, Ma RC, Okada Y, Iwata M, Hosoe J, Shojima N, Iwasaki M, Fujita H, Suzuki K, Danesh J, Jørgensen T, Jørgensen ME, Witte DR, Brandslund I, Christensen C, Hansen T, Mercader JM, Flannick J, Moreno-Macías H, Burtt NP, Zhang R, Kim YJ, Zheng W, Zheng W, Singh JR, Tam CH, Hirose H, Maegawa H, Ito C, Kaku K, Watada H, Tanaka Y, Tobe K, Kawamori R, Kubo M, Cho YS, Chan JC, Sanghera D, Frossard P, Park KS, Shu XO, Kim BJ, Florez JC, Tusié-Luna T, Jia W, Tai ES, Pedersen O, Saleheen D, Maeda S, Kadowaki T
Nature communications · 2016 · PMID 26818947 · open access

Questions about rs78627331

What is rs78627331?

rs78627331 is a single position in the genome, in or near the IDE gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs78627331 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs78627331 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs78627331 come from?

GWAS Catalog, Nature communications 2016, PMID:26818947. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 2 diabetes (rs78627331). MyGeneLog™. https://www.mygenelog.com/variants/rs78627331

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